Tiotropium bromide

Name: Tiotropium bromide
Brand: Tocris Bioscience
SKU: 5902

Tocris Bioscience, part of Bio-Techne | Catalog # 5902

Citations (3)

COA / SDS

Potent muscarinic receptor antagonist

Key Product Details

Description:	Potent muscarinic receptor antagonist
Alternative Names:	Ba 679 BR
Chemical Name:	(1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0^2,4]nonane bromide
Purity:	≥98% (HPLC)
Molecular Weight:	472.42

View Full Technical Details for Tiotropium bromide

Technical Data
Citations

Biological Activity for Tiotropium bromide

Tiotropium bromide is a potent muscarinic receptor antagonist. Inhibits electrical field stimulation-induced contraction of guinea pig trachea in vitro (IC₅₀ = 0.17 nM). Induces smooth muscle relaxation and bronchodilation.

Compound Libraries for Tiotropium bromide

Tiotropium bromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Tiotropium bromide

M. Wt	472.42
Formula	C₁₉H₂₂BrNO₄S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	136310-93-5
PubChem ID	5487426
InChi Key	DQHNAVOVODVIMG-RGECMCKFSA-M
Smiles	C[N+]1(C)[C@]2([H])[C@H]3[C@H](O3)[C@@]1([H])C[C@@H](OC(C(C4=CC=CS4)(O)C5=CC=CS5)=O)C2.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tiotropium bromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	9.45	20
	DMSO	47.24	100

Preparing Stock Solutions for Tiotropium bromide

The following data is based on the product molecular weight 472.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.58 mL	21.17 mL
5 mM	0.42 mL	2.12 mL	4.23 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for Tiotropium bromide

References are publications that support the biological activity of the product.

Smit Bronchoprotection by olodaterol is synergistically enhanced by tiotr. in a guinea pig model of allergic asthma. J.Pharmacol.Exp.Ther. 2014 PMID: 24307202
Ogoda Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrr. J.Pharm.Sci. 2011 PMID: 21358117
Takahashi Effect of Ba 679 BR, a novel long-acting anticholin. agent, on cholinergic neurotransmission in guinea pig and human airways. Am.J.Respir.Crit.Care Med. 1994 PMID: 7952627