Tizanidine hydrochloride

Name: Tizanidine hydrochloride
Brand: Tocris Bioscience
SKU: 3609

Tocris Bioscience, part of Bio-Techne | Catalog # 3609

Citations (1)

COA / SDS

α2 agonist

Key Product Details

Description:	α₂ agonist
Chemical Name:	5-(Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	290.17

View Full Technical Details for Tizanidine hydrochloride

Technical Data
Citations

Biological Activity for Tizanidine hydrochloride

Tizanidine hydrochloride is an α₂-adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC₅₀ = 48 nM). Also binds to imidazoline receptor.

Compound Libraries for Tizanidine hydrochloride

Tizanidine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Tizanidine hydrochloride

M. Wt	290.17
Formula	C₉H₈ClN₅S.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	64461-82-1
PubChem ID	114869
InChi Key	ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
Smiles	ClC2=C(NC3=NCCN3)C1=NSN=C1C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tizanidine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	29.02	100
	DMSO	29.02	100

Preparing Stock Solutions for Tizanidine hydrochloride

The following data is based on the product molecular weight 290.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.45 mL	17.23 mL	34.46 mL
5 mM	0.69 mL	3.45 mL	6.89 mL
10 mM	0.34 mL	1.72 mL	3.45 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

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Reconstitution Calculator

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References for Tizanidine hydrochloride

References are publications that support the biological activity of the product.

Piletz Autoradiographic comparison of [³H]-Clonidine binding to non-adrenergic sites and α₂-adrenergic receptors in human brain. Neuropsychopharmacology 2000 PMID: 11063925
Asano Antinociception by epidural and systemic α₂-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth.Analg. 2000 PMID: 10648329