TL4-12

Name: TL4-12
Brand: Tocris Bioscience
SKU: 5910

Tocris Bioscience, part of Bio-Techne | Catalog # 5910

Citations (1)

COA / SDS

Potent MAP4K2 (GCK) inhibitor

Key Product Details

Chemical Name:	4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for TL4-12

TL4-12 is a potent MAP4K2 (GCK) inhibitor (IC₅₀ = 37 nM). Exhibits >70-fold selectivity for MAP4K2 over TAK1 (IC₅₀ = 2.7 μM for TAK1). Inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation, in vitro.

Technical Data for TL4-12

Formula	C₂₅H₂₇F₃N₆O₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	1620820-12-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TL4-12

Solubility

Soluble Soluble to 20 mM in DMSO and to 20 mM in 1eq. HCl

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References for TL4-12

References are publications that support the biological activity of the product.

Tan et al. Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J.Med.Chem., 2015;58:183 PMID: 25075558

TL4-12

Tocris Bioscience, part of Bio-Techne | Catalog # 5910

Key Product Details

Biological Activity for TL4-12

Technical Data for TL4-12

Solubility for TL4-12

Dilution Calculator

Reconstitution Calculator

References for TL4-12

Product Documents for TL4-12

COA

Certificate of Analysis

SDS

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