TMPyP4 tosylate

Name: TMPyP4 tosylate
Brand: Tocris Bioscience
SKU: 4253

Tocris Bioscience, part of Bio-Techne | Catalog # 4253

Citations (3)

COA / SDS

Inhibitor of human telomerase

Key Product Details

Description:	Inhibitor of human telomerase
Chemical Name:	5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate)
Purity:	≥95% (HPLC)
Molecular Weight:	1363.6

View Full Technical Details for TMPyP4 tosylate

Technical Data
Citations

Biological Activity for TMPyP4 tosylate

TMPyP4 tosylate is a cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.

Technical Data for TMPyP4 tosylate

M. Wt	1363.6
Formula	C₇₂H₆₆N₈O₁₂S₄
Storage	Store at +4°C
Purity	≥95% (HPLC)
CAS Number	36951-72-1
PubChem ID	11979833
InChi Key	AKZFRMNXBLFDNN-UHFFFAOYSA-K
Smiles	CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(C=C1)S([O-])(=O)=O.C[N+]1=CC=C(C=C1)C1=C2\C=CC(=N2)\C(=C2/N\C(\C=C2)=C(/C2=N/C(/C=C2)=C(\C2=CC=C\1N2)C1=CC=[N+](C)C=C1)C1=CC=[N+](C)C=C1)\C1=CC=[N+](C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TMPyP4 tosylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	68.18	50

Preparing Stock Solutions for TMPyP4 tosylate

The following data is based on the product molecular weight 1363.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	1.47 mL	7.33 mL	14.67 mL
2.5 mM	0.29 mL	1.47 mL	2.93 mL
5 mM	0.15 mL	0.73 mL	1.47 mL
25 mM	0.03 mL	0.15 mL	0.29 mL

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References for TMPyP4 tosylate

References are publications that support the biological activity of the product.

Shi Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J.Med.Chem.
Shammas Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol.Cancer Ther. 2003 PMID: 14555701
Wheelhouse Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA. J.Am.Chem.Soc.
Rha Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin.Cancer Res. 2000 PMID: 10741725