Tubastatin A hydrochloride

Name: Tubastatin A hydrochloride
Brand: Tocris Bioscience
SKU: 6270

Tocris Bioscience, part of Bio-Techne | Catalog # 6270

Citations (5)

COA / SDS

Potent HDAC6 inhibitor

Key Product Details

Description:	Potent HDAC6 inhibitor
Chemical Name:	N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	371.86

View Full Technical Details for Tubastatin A hydrochloride

Technical Data
Citations

Biological Activity for Tubastatin A hydrochloride

Tubastatin A hydrochloride is a potent HDAC6 inhibitor (IC₅₀ = 0.015 μM). Exhibits some selectively for HDAC6 over HDAC8 and 1 (IC₅₀ values are 0.854 and 16.4 μM, respectively). Induces elevated levels of α-tubulin and protects against glutathione-induced oxidative stress in primary neuronal cell culture. Reverses the axonal loss in peripheral neurons in a mouse model of Charcot-Marie-Tooth disease.

Technical Data for Tubastatin A hydrochloride

M. Wt	371.86
Formula	C₂₀H₂₁N₃O₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1310693-92-5
PubChem ID	57336514
InChi Key	LJTSJTWIMOGKRJ-UHFFFAOYSA-N
Smiles	CN1CCC2=C(C3=CC=CC=C3N2CC4=CC=C(C(NO)=O)C=C4)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tubastatin A hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.72	10 with gentle warming

Preparing Stock Solutions for Tubastatin A hydrochloride

The following data is based on the product molecular weight 371.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.89 mL	134.46 mL	268.92 mL
0.5 mM	5.38 mL	26.89 mL	53.78 mL
1 mM	2.69 mL	13.45 mL	26.89 mL
5 mM	0.54 mL	2.69 mL	5.38 mL

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References for Tubastatin A hydrochloride

References are publications that support the biological activity of the product.

d'Ydewalle HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease. Nature medicine 2011 PMID: 21785432
Butler Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A J.Am.Chem.Soc.