(+)-Tubocurarine chloride

Name: (+)-Tubocurarine chloride
Brand: Tocris Bioscience
SKU: 2820
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2820

(1)

Citations (25)

COA / SDS

nAChR antagonist

Key Product Details

Description:	nAChR antagonist
Chemical Name:	2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	681.65

View Full Technical Details for (+)-Tubocurarine chloride

Technical Data
Citations / Reviews (1)

Biological Activity for (+)-Tubocurarine chloride

(+)-Tubocurarine chloride is a competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT₃ and GABA_A receptor antagonist.

Technical Data for (+)-Tubocurarine chloride

M. Wt	681.65
Formula	C₃₇H₄₁ClN₂O₆.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	57-94-3
PubChem ID	64645
InChi Key	GXFZCDMWGMFGFL-KKXMJGKMSA-N
Smiles	OC1=C(OC)C=C3C([C@@H]7[N+](C)(C)CC3)=C1OC(C=C5)=CC=C5C[C@H](N(C)CC4)C2=C4C=C(OC)C(OC6=C(O)C=CC(C7)=C6)=C2.[Cl-].Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-Tubocurarine chloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	17.04	25

Preparing Stock Solutions for (+)-Tubocurarine chloride

The following data is based on the product molecular weight 681.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	5.87 mL	29.34 mL	58.68 mL
1.25 mM	1.17 mL	5.87 mL	11.74 mL
2.5 mM	0.59 mL	2.93 mL	5.87 mL
12.5 mM	0.12 mL	0.59 mL	1.17 mL

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References for (+)-Tubocurarine chloride

References are publications that support the biological activity of the product.

Peters Antagonism of 5-HT₃ receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci.Letts.
Wotring and Yoon The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons. Neurosci.
Pederson and Cohen d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA