Tunicamycin

Name: Tunicamycin
Brand: Tocris Bioscience
SKU: 3516
Rating: 5 (4 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3516

(4)

Citations (79)

COA / SDS

Antibiotic; GlcNAc phosphotransferase inhibitor

Key Product Details

Description:	Antibiotic; GlcNAc phosphotransferase inhibitor
Chemical Name:	Tunicamycin from Streptomyces sp.
Purity:	≥98% (HPLC)
Molecular Weight:	844.95

View Full Technical Details for Tunicamycin

Technical Data
Citations / Reviews (4)

Biological Activity for Tunicamycin

Tunicamycin is an antibiotic; inhibits GlcNAc phosphotransferase (GPT). Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Activity induces ER stress and causes G₁ arrest; can be used to induce autophagy. Tunicamycin contains four main components as follows:

Homolog A, n=8, C₃₇H₆₀N₄O₁₆, molecular weight = 816.90
Homolog B, n=9, C₃₈H₆₂N₄O₁₆, molecular weight = 830.93
Homolog C, n=10, C₃₉H₆₄N₄O₁₆, molecular weight = 844.95
Homolog D, n=11, C₄₀H₆₆N₄O₁₆, molecular weight = 858.99

The composition of this product will vary from batch to batch and can be found on the relevant certificate of analysis.

Technical Data for Tunicamycin

M. Wt	844.95
Formula	C₃₉H₆₄N₄O₁₆ (tunicamycin C, n=10)
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	11089-65-9
PubChem ID	90488851
InChi Key	ZOCXUHJGZXXIGQ-SQXRCPDGSA-N
Smiles	O=C(C=C3)NC(N3[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)[C@H](O)C[C@@H]1[C@H](O)[C@H](O)[C@@H](NC(/C=C/CCCCCCCCCCC(C)C)=O)[C@H](OC4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4NC(C)=O)O1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tunicamycin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.25	50

Preparing Stock Solutions for Tunicamycin

The following data is based on the product molecular weight 844.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.37 mL	11.84 mL	23.67 mL
2.5 mM	0.47 mL	2.37 mL	4.73 mL
5 mM	0.24 mL	1.18 mL	2.37 mL
25 mM	0.05 mL	0.24 mL	0.47 mL

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References for Tunicamycin

References are publications that support the biological activity of the product.

Lauer Primary murine airway smooth muscle cells exposed to poly(I:C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix. J.Biol.Chem. 2009 PMID: 19088077
Ding Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 2007 PMID: 17135238
Duriez The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated pathway. J.Biol.Chem. 2008 PMID: 18805786