TY 52156

Name: TY 52156
Brand: Tocris Bioscience
SKU: 5328

Tocris Bioscience, part of Bio-Techne | Catalog # 5328

Citations (24)

COA / SDS

S1P3 receptor antagonist

Key Product Details

Description:	S1P₃ receptor antagonist
Chemical Name:	N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	364.27

View Full Technical Details for TY 52156

Technical Data
Citations

Biological Activity for TY 52156

TY 52156 is an S1P₃ receptor antagonist (K_i = 110 nM); inhibits S1P-induced Ca²⁺ release in HUVEC cells. Suppresses FTY-720-induced S1P₃ receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.

Compound Libraries for TY 52156

TY 52156 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TY 52156

M. Wt	364.27
Formula	C₁₈H₁₉Cl₂N₃O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	934369-14-9
PubChem ID	16046248
InChi Key	XONRRGIRSGNWFP-UHFFFAOYSA-N
Smiles	ClC1=CC=C(/N=C(NNC2=CC=C(Cl)C=C2)/C(C(C)(C)C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TY 52156

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.43	100
	ethanol	36.43	100

Preparing Stock Solutions for TY 52156

The following data is based on the product molecular weight 364.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.73 mL	27.45 mL
5 mM	0.55 mL	2.75 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.75 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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References for TY 52156

References are publications that support the biological activity of the product.

Hirata Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR₃ by a ligand-independent Notch activation. Nat.Commun. 2014 PMID: 25254944
Murakami Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P₃ receptor: investigation based on a new S1P₃ receptor antagonist. Mol.Pharmacol. 2010 PMID: 20097776