(±)-U-50488 hydrochloride

Name: (±)-U-50488 hydrochloride
Brand: Tocris Bioscience
SKU: 0495

Tocris Bioscience, part of Bio-Techne | Catalog # 0495

(4)

Citations (10)

COA / SDS

Selective κ agonist

Key Product Details

Chemical Name:	trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Purity:	≥99%
Molecular Weight:	405.79 kDa

View Full Technical Details for (±)-U-50488 hydrochloride

Technical Data
Citations / Reviews (4)

Biological Activity for (±)-U-50488 hydrochloride

(±)-U-50488 hydrochloride is a selective κ-opioid agonist. At higher concentrations blocks Na⁺ channels.

(-)-enantiomer and (+)-enantiomer also available.

Technical Data for (±)-U-50488 hydrochloride

M. Wt	405.79 kDa
Formula	C₁₉H₂₆Cl₂N₂O.HCl
Storage	Store at RT
Purity	≥99%
CAS Number	67197-96-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-U-50488 hydrochloride

Solubility

Soluble Soluble to 25 mM in water

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References for (±)-U-50488 hydrochloride

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Zhou L, Lovell K, Frankowski K, Slauson S, Phillips A, Streicher J, Stahl E, Schmid C, Hodder P, Madoux F, Cameron M, Prisinzano T, Aube J, Bohn L Development of functionally selective, small molecule agonists at kappa opioid receptors. J Biol Chem, 2013;288(51):36703-16. 2013 PMID: 24187130
Kharmate G, Rajput P, Lin Y, Kumar U Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells. Cancer Cell Int, 2013;13(1):93. 2013 PMID: 24059654
Pugsley et al. Cardiovascular actions of the κ-agonist, U-50-488H, in the absence and presence of opioid receptor blockade. Br.J.Pharmacol., 1992;105:521 PMID: 1320979
Pao-Luh Tao et al. U-50,488 blocks the development of mor. tolerance and dependence at a very low dose in guinea pigs. Eur.J.Pharmacol., 1994;256:281 PMID: 8045272
Suarez-Roca and Maixner Activation of kappa opioid receptors by U-50488H and mor. enhances the release of substance P from rat trigeminal nucleus slices. J.Pharmacol.Exp.Ther., 1993;264:648 PMID: 7679733
Su et al. Blockade of the development of mor. tolerance by U-50,488, an AVP antagonist or MK 801 in the rat hippocampal slice. Br.J.Pharmacol., 1998;123:625 PMID: 9517380