UK 14,304

Name: UK 14,304
Brand: Tocris Bioscience
SKU: 0425

Tocris Bioscience, part of Bio-Techne | Catalog # 0425

Citations (33)

COA / SDS

α2 agonist

Key Product Details

Description:	α₂ agonist
Chemical Name:	5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline
Molecular Weight:	292.14

View Full Technical Details for UK 14,304

Technical Data
Citations

Biological Activity for UK 14,304

UK 14,304 is a full α₂ adrenergic agonist. Centrally active following systemic administration in vivo.

Water-soluble Salt also available.

Compound Libraries for UK 14,304

UK 14,304 is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for UK 14,304

M. Wt	292.14
Formula	C₁₁H₁₀BrN₅
Storage	Store at RT
CAS Number	59803-98-4
PubChem ID	2435
InChi Key	XYLJNLCSTIOKRM-UHFFFAOYSA-N
Smiles	BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UK 14,304

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for UK 14,304

The following data is based on the product molecular weight 292.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.42 mL	17.12 mL	34.23 mL
5 mM	0.68 mL	3.42 mL	6.85 mL
10 mM	0.34 mL	1.71 mL	3.42 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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Reconstitution Calculator

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References for UK 14,304

References are publications that support the biological activity of the product.

Chopin Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxyDA lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 1999 PMID: 9918591
Macdonald Gene targeting - homing in on α₂-adrenoceptor-subtype function. TiPS 1997 PMID: 9227000
Andorn Specific [³H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α₂-adrenergic selectivity and different affinities for GTP. Life Sci. 1988 PMID: 2904634