UoS 12258

Name: UoS 12258
Brand: Tocris Bioscience
SKU: 6353

Tocris Bioscience, part of Bio-Techne | Catalog # 6353

COA / SDS

Positive allosteric modulator of AMPA receptors

Key Product Details

Description:	Positive allosteric modulator of AMPA receptors
Chemical Name:	N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	334.41

View Full Technical Details for UoS 12258

Technical Data
Citations

Biological Activity for UoS 12258

UoS 12258 is a positive allosteric modulator of AMPA receptors (pEC₅₀ = 5.2 for potentiation of AMPA-mediated currents in vitro). Also potentiates AMPA-mediated synaptic responses in vivo. Improves performance of rats in various learning and memory paradigms

Compound Libraries for UoS 12258

UoS 12258 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for UoS 12258

M. Wt	334.41
Formula	C₁₇H₁₉FN₂O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	875927-64-3
PubChem ID	46398805
InChi Key	QXQSUBKWSHMXDP-INIZCTEOSA-N
Smiles	CC(S(=O)(N[C@H]1CC2=CC=C(C3=CN=C(C=C3)F)C=C2C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UoS 12258

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.44	100

Preparing Stock Solutions for UoS 12258

The following data is based on the product molecular weight 334.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.99 mL	14.95 mL	29.90 mL
5 mM	0.60 mL	2.99 mL	5.98 mL
10 mM	0.30 mL	1.50 mL	2.99 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for UoS 12258

References are publications that support the biological activity of the product.

Ward Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator. Br.J.Pharmacol. 2017 PMID: 28009436
Ward Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. J.Med.Chem. 2010 PMID: 20614889