uPSEM 792 hydrochloride

Name: uPSEM 792 hydrochloride
Brand: Tocris Bioscience
SKU: 6865

Tocris Bioscience, part of Bio-Techne | Catalog # 6865

Citations (4)

COA / SDS

Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant

Key Product Details

Description:	Highly potent PSAM⁴-GlyR and PSAM⁴-5-HT₃ chimeric ion channel agonist; brain-penetrant
Chemical Name:	1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	277.75

View Full Technical Details for uPSEM 792 hydrochloride

Technical Data
Citations

Biological Activity for uPSEM 792 hydrochloride

uPSEM 792 hydrochloride is an ultrapotent PSEM (uPSEM) agonist for PSAM⁴-GlyR and PSAM⁴-5HT3 (K_i = 0.7 nM for PSAM⁴-GlyR and <10 nM for PSAM⁴-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM⁴-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (~10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM⁴-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetrant.

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

Technical Data for uPSEM 792 hydrochloride

M. Wt	277.75
Formula	C₁₄H₁₅N₃O.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2341841-08-3
InChi Key	CDHPEJUYEXNGCV-UHFFFAOYSA-N
Smiles	O=C1C=NC2=C(C=C3C(C4CNCC3C4)=C2)N1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for uPSEM 792 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	27.77	100

Preparing Stock Solutions for uPSEM 792 hydrochloride

The following data is based on the product molecular weight 277.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.60 mL	18.00 mL	36.00 mL
5 mM	0.72 mL	3.60 mL	7.20 mL
10 mM	0.36 mL	1.80 mL	3.60 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for uPSEM 792 hydrochloride

References are publications that support the biological activity of the product.

Magnus Ultrapotent chemogenetics for research and potential clinical applications. Science 2019 PMID: 30872534