uPSEM 792 hydrochloride

Name: uPSEM 792 hydrochloride
Brand: Tocris Bioscience
SKU: 6865

Tocris Bioscience, part of Bio-Techne | Catalog # 6865

Citations (4)

COA / SDS

Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant

Key Product Details

Chemical Name:	1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride
Purity:	≥98%

View Full Technical Details for uPSEM 792 hydrochloride

Technical Data
Citations

Biological Activity for uPSEM 792 hydrochloride

uPSEM 792 hydrochloride is an ultrapotent PSEM (uPSEM) agonist for PSAM⁴-GlyR and PSAM⁴-5HT3 (K_i = 0.7 nM for PSAM⁴-GlyR and <10 nM for PSAM⁴-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM⁴-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (~10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM⁴-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetrant.

Technical Data for uPSEM 792 hydrochloride

Formula	C₁₄H₁₅N₃O.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	2341841-08-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for uPSEM 792 hydrochloride

Solubility

Soluble Soluble to 100 mM in water

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for uPSEM 792 hydrochloride

References are publications that support the biological activity of the product.

Magnus et al. Ultrapotent chemogenetics for research and potential clinical applications. Science, 2019; PMID: 30872534

uPSEM 792 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6865

Key Product Details

Biological Activity for uPSEM 792 hydrochloride

Technical Data for uPSEM 792 hydrochloride

Solubility for uPSEM 792 hydrochloride

Dilution Calculator

Reconstitution Calculator

References for uPSEM 792 hydrochloride

Product Documents for uPSEM 792 hydrochloride

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected