uPSEM 817 tartrate

Name: uPSEM 817 tartrate
Brand: Tocris Bioscience
SKU: 6866

Tocris Bioscience, part of Bio-Techne | Catalog # 6866

Citations (3)

COA / SDS

Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant

Key Product Details

Chemical Name:	2-Propoxy-7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline L-tartrate
Purity:	≥98%

View Full Technical Details for uPSEM 817 tartrate

Technical Data
Citations

Biological Activity for uPSEM 817 tartrate

uPSEM 817 tartrate is a selective ultrapotent PSEM (uPSEM) agonist for α7^{L131G,Q139L,Y217F}-GlyR (PSAM⁴-GlyR) and PSAM⁴-5-HT₃ chimeric ion channels (EC₅₀ values are 0.3 and 0.5 nM, respectively). Suppresses firing of layer 2/3 cortical neurons expressing PSAM⁴-GlyR in brain slices. Increases contralateral rotation in mice expressing PSAM⁴-GlyR unilaterally in the substantia nigra reticulata (LED 0.1 mg/kg).

Technical Data for uPSEM 817 tartrate

Formula	C₁₆H₁₉N₃O.C₄H₆O₆
Storage	Store at -20°C
Purity	≥98%
CAS Number	2341833-14-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for uPSEM 817 tartrate

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in water

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References for uPSEM 817 tartrate

References are publications that support the biological activity of the product.

Magnus et al. Ultrapotent chemogenetics for research and potential clinical applications. Science, 2019; PMID: 30872534

uPSEM 817 tartrate

Tocris Bioscience, part of Bio-Techne | Catalog # 6866

Key Product Details

Biological Activity for uPSEM 817 tartrate

Technical Data for uPSEM 817 tartrate

Solubility for uPSEM 817 tartrate

Dilution Calculator

Reconstitution Calculator

References for uPSEM 817 tartrate

Product Documents for uPSEM 817 tartrate

COA

Certificate of Analysis

SDS

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