URB 597

Name: URB 597
Brand: Tocris Bioscience
SKU: 4612

Tocris Bioscience, part of Bio-Techne | Catalog # 4612

Citations (57)

COA / SDS

Potent and selective FAAH inhibitor

Key Product Details

Description:	Potent and selective FAAH inhibitor
Chemical Name:	Cyclohexylcarbamic acid 3'-(Aminocarbonyl)-[1,1'-biphenyl]-3-yl ester
Purity:	≥99% (HPLC)
Molecular Weight:	338.4

View Full Technical Details for URB 597

Technical Data
Citations

Biological Activity for URB 597

URB 597 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC₅₀ values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.

Technical Data for URB 597

M. Wt	338.4
Formula	C₂₀H₂₂N₂O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	546141-08-6
PubChem ID	1383884
InChi Key	ROFVXGGUISEHAM-UHFFFAOYSA-N
Smiles	NC(C1=CC(C2=CC=CC(OC(NC3CCCCC3)=O)=C2)=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for URB 597

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	16.92	50

Preparing Stock Solutions for URB 597

The following data is based on the product molecular weight 338.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.91 mL	29.55 mL	59.10 mL
2.5 mM	1.18 mL	5.91 mL	11.82 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
25 mM	0.12 mL	0.59 mL	1.18 mL

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References for URB 597

References are publications that support the biological activity of the product.

Piomelli Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 2006 PMID: 16834756
Jayamanne Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br.J.Pharmacol. 2006 PMID: 16331291
Hohmann An endocannabinoid mechanism for stress-induced analgesia. Nature 2005 PMID: 15973410