Valsartan

Name: Valsartan
Brand: Tocris Bioscience
SKU: 4216

Tocris Bioscience, part of Bio-Techne | Catalog # 4216

Citations (10)

COA / SDS

High affinity, selective AT1 antagonist

Key Product Details

Description:	High affinity, selective AT₁ antagonist
Alternative Names:	CGP 48933
Chemical Name:	(S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]butanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	435.52

View Full Technical Details for Valsartan

Technical Data
Citations

Biological Activity for Valsartan

Valsartan is a high affinity AT₁ receptor antagonist (K_i = 2.38 nM). Displays 30,000-fold selectivity over AT₂ receptors. Inhibits angiotensin II-induced release of aldosterone in vitro. Orally active.

Compound Libraries for Valsartan

Valsartan is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Valsartan

M. Wt	435.52
Formula	C₂₄H₂₉N₅O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	137862-53-4
PubChem ID	60846
InChi Key	ACWBQPMHZXGDFX-QFIPXVFZSA-N
Smiles	CC(C)[C@@H]([C@@](O)=O)N(C(CCCC)=O)CC(C=C3)=CC=C3C1=CC=CC=C1C2=NN=NN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Valsartan

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.55	100

Preparing Stock Solutions for Valsartan

The following data is based on the product molecular weight 435.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.48 mL	22.96 mL
5 mM	0.46 mL	2.30 mL	4.59 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Reconstitution Calculator

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References for Valsartan

References are publications that support the biological activity of the product.

Wexler Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J.Med.Chem. 1996 PMID: 8576904
Hanafy Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers. Br.J.Pharmacol. 2008 PMID: 17965735
Criscione Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT₁-receptor subtype. Br.J.Pharmacol. 1993 PMID: 8242249