VPC 23019

Name: VPC 23019
Brand: Tocris Bioscience
SKU: 4195

Tocris Bioscience, part of Bio-Techne | Catalog # 4195

Citations (29)

COA / SDS

S1P1 and S1P3 antagonist

Key Product Details

Description:	S1P₁ and S1P₃ antagonist
Chemical Name:	2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide
Purity:	≥95% (HPLC)
Molecular Weight:	372.4

View Full Technical Details for VPC 23019

Technical Data
Citations

Biological Activity for VPC 23019

VPC 23019 is a sphingosine-1-phosphate receptor antagonist; inhibits S1P₁ and S1P₃ receptors (pK_i values are 7.86 and 5.93 respectively).

Technical Data for VPC 23019

M. Wt	372.4
Formula	C₁₇H₂₉N₂O₅P
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	449173-19-7
PubChem ID	11588811
InChi Key	MRUSUGVVWGNKFE-MRXNPFEDSA-N
Smiles	O=C([C@H](N)COP(O)(O)=O)NC1=CC(CCCCCCCC)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VPC 23019

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	Acidified DMSO (5% 1N HCl in DMSO)	3.72	10 with gentle warming
	2eq. NaOH	18.62	50

Preparing Stock Solutions for VPC 23019

The following data is based on the product molecular weight 372.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.37 mL	26.85 mL	53.71 mL
2.5 mM	1.07 mL	5.37 mL	10.74 mL
5 mM	0.54 mL	2.69 mL	5.37 mL
25 mM	0.11 mL	0.54 mL	1.07 mL

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References for VPC 23019

References are publications that support the biological activity of the product.

Aoki The suppressive effect of sphingosine-1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α₅β₁ and α_Vβ₃. J.Thromb.Haemost. 2007 PMID: 17403093
Mihovilovic High-fat/cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. J.Lipid Res. 2007 PMID: 17264352
Davis Sphingosine-1-phosphate analogs as receptor antagonists. J.Biol.Chem. 2005 PMID: 15590668