VU 0134992

Name: VU 0134992
Brand: Tocris Bioscience
SKU: 6877

Tocris Bioscience, part of Bio-Techne | Catalog # 6877

Citations (6)

COA / SDS

Kir4.1 blocker

Key Product Details

Description:	K_ir4.1 blocker
Chemical Name:	2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	411.38

View Full Technical Details for VU 0134992

Technical Data
Citations

Biological Activity for VU 0134992

VU 0134992 is a K_ir4.1 potassium channel blocker (IC₅₀ = 0.97 μM). Displays 10-fold selectivity for K_ir4.1 over K_ir4.1/5.1 concatemeric channels and >30-fold selectivity over K_ir1.1, 2.1 and 2.2. Increases urine output and urinary Na⁺ and K⁺ excretion in volume-loaded rats.

Compound Libraries for VU 0134992

VU 0134992 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VU 0134992

M. Wt	411.38
Formula	C₂₀H₃₁BrN₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	755002-90-5
PubChem ID	1319582
InChi Key	OTTDLWFVHQYRDA-UHFFFAOYSA-N
Smiles	CC(C)C1=CC(Br)=C(OCC(=O)NC2CC(C)(C)NC(C)(C)C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 0134992

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.14	100
	ethanol	41.14	100

Preparing Stock Solutions for VU 0134992

The following data is based on the product molecular weight 411.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.15 mL	24.31 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
10 mM	0.24 mL	1.22 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for VU 0134992

References are publications that support the biological activity of the product.

Kharade Discovery, characterization, and effects on renal fluid and electrolyte excretion of the K_ir4.1 potassium channel pore blocker, VU0134992. Mol.Pharmacol. 2018 PMID: 29895592