VU 0409106

Name: VU 0409106
Brand: Tocris Bioscience
SKU: 5322

Tocris Bioscience, part of Bio-Techne | Catalog # 5322

COA / SDS

Potent and selective negative allosteric modulator of mGlu5 receptors

Discontinued Product

5322 has been discontinued. View all Group I mGluR Modulators products.

Key Product Details

Description:	Potent and selective negative allosteric modulator of mGlu₅ receptors
Chemical Name:	3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	330.34

View Full Technical Details for VU 0409106

Technical Data
Citations

Biological Activity for VU 0409106

VU 0409106 is a potent and selective mGlu₅ negative allosteric modulator (IC₅₀ = 49 nM at human mGlu₅). Selective for mGlu₅ over a panel of GPCRs and ion channels. Exhibits no significant nonspecific binding in rat brain homogenates in vitro. Inhibits marble burying behavior in mice. Brain penetrant.

Compound Libraries for VU 0409106

VU 0409106 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VU 0409106

M. Wt	330.34
Formula	C₁₅H₁₁FN₄O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1276617-62-9
PubChem ID	50990953
InChi Key	AXVLPJHYYFHCHK-UHFFFAOYSA-N
Smiles	FC1=CC(OC2=CN=CN=C2)=CC(C(NC3=NC(C)=CS3)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VU 0409106

References are publications that support the biological activity of the product.

Felts Discovery of VU0409106: A negative allosteric modulator of mGlu₅ with activity in a mouse model of anxiety. Bioorg.Med.Chem.Lett. 2013 PMID: 24074843