WAY 161503 hydrochloride

Name: WAY 161503 hydrochloride
Brand: Tocris Bioscience
SKU: 1801

Tocris Bioscience, part of Bio-Techne | Catalog # 1801

Citations (9)

COA / SDS

Potent and selective 5-HT2C agonist

Key Product Details

Description:	Potent and selective 5-HT_2C agonist
Chemical Name:	8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	308.59

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Technical Data
Citations

Biological Activity for WAY 161503 hydrochloride

WAY 161503 hydrochloride is a potent and selective 5-HT_2C receptor agonist (K_i = 4 nM; EC₅₀ = 12 nM). Shows approximately 2-fold selectivity for 5HT_2C over 5HT_2A in HEK293 cell lines (EC₅₀= 7.3 nM and 12 nM, respectively). Antidepressant following systemic administration in vivo.

Technical Data for WAY 161503 hydrochloride

M. Wt	308.59
Formula	C₁₁H₁₁Cl₂N₃O.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	276695-22-8
PubChem ID	21976692
InChi Key	YPNWSZJDAKOUAW-UHFFFAOYSA-N
Smiles	Cl.ClC1=CC2=C(C=C1Cl)N1CCNCC1C(=O)N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for WAY 161503 hydrochloride

References are publications that support the biological activity of the product.

Welmaker Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg.Med.Chem.Lett. 2000 PMID: 10987434
Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
Cryan and Lucki Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine_2C receptors. J.Pharmacol.Exp.Ther. 2000 PMID: 11082448

WAY 161503 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1801

Key Product Details

Biological Activity for WAY 161503 hydrochloride

Technical Data for WAY 161503 hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for WAY 161503 hydrochloride

Product Documents for WAY 161503 hydrochloride

COA

Certificate of Analysis

SDS

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