WAY 208466 dihydrochloride

Name: WAY 208466 dihydrochloride
Brand: Tocris Bioscience
SKU: 3904

Tocris Bioscience, part of Bio-Techne | Catalog # 3904

Citations (3)

COA / SDS

Selective 5-HT6 agonist

Key Product Details

Description:	Selective 5-HT₆ agonist
Chemical Name:	3-[(-3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	420.33

View Full Technical Details for WAY 208466 dihydrochloride

Technical Data
Citations

Biological Activity for WAY 208466 dihydrochloride

WAY 208466 dihydrochloride is a high affinity, selective 5-HT₆ agonist (EC₅₀ = 7.3 nM at the human 5-HT₆ receptor). Elevates cortical GABA levels in vivo in rat frontal cortex. Exhibits antidepressant and anxiolytic-like effects.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for WAY 208466 dihydrochloride

WAY 208466 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WAY 208466 dihydrochloride

M. Wt	420.33
Formula	C₁₇H₁₈FN₃O₂S.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1207064-61-6
PubChem ID	22028182
InChi Key	BAOHMLBVCLITHA-UHFFFAOYSA-N
Smiles	O=S(C2=CN(CCN(C)C)C1=NC=CC=C12)(C3=CC=CC(F)=C3)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WAY 208466 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	33.63	80
	DMSO	33.63	80

Preparing Stock Solutions for WAY 208466 dihydrochloride

The following data is based on the product molecular weight 420.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.8 mM	2.97 mL	14.87 mL	29.74 mL
4 mM	0.59 mL	2.97 mL	5.95 mL
8 mM	0.30 mL	1.49 mL	2.97 mL
40 mM	0.06 mL	0.30 mL	0.59 mL

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References for WAY 208466 dihydrochloride

References are publications that support the biological activity of the product.

Carr Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacol.(Berl.) 2010 PMID: 20217056
Schechter Neuropharmacological profile of novel and selective 5-HT₆ receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacol 2008 PMID: 17625499