WAY 208466 dihydrochloride

Name: WAY 208466 dihydrochloride
Brand: Tocris Bioscience
SKU: 3904

Tocris Bioscience, part of Bio-Techne | Catalog # 3904

Citations (3)

COA / SDS

Selective 5-HT6 agonist

Key Product Details

Chemical Name:	3-[(-3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine dihydrochloride
Purity:	≥99%
Molecular Weight:	420.33 kDa

View Full Technical Details for WAY 208466 dihydrochloride

Technical Data
Citations

Biological Activity for WAY 208466 dihydrochloride

WAY 208466 dihydrochloride is a high affinity, selective 5-HT₆ agonist (EC₅₀ = 7.3 nM at the human 5-HT₆ receptor). Elevates cortical GABA levels in vivo in rat frontal cortex. Exhibits antidepressant and anxiolytic-like effects.

Technical Data for WAY 208466 dihydrochloride

M. Wt	420.33 kDa
Formula	C₁₇H₁₈FN₃O₂S.2HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	1207064-61-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WAY 208466 dihydrochloride

Solubility

Soluble Soluble to 80 mM in water and to 80 mM in DMSO

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for WAY 208466 dihydrochloride

References are publications that support the biological activity of the product.

Amireault P, Bayard E, Launay J, Sibon D, Le Van Kim C, Colin Y, Dy M, Hermine O, Cote F Serotonin is a key factor for mouse red blood cell survival. PLoS ONE, 2013;8(12):e83010. 2013 PMID: 24358245
Schechter et al. Neuropharmacological profile of novel and selective 5-HT₆ receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacol, 2008;33:1323 PMID: 17625499
Carr et al. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacol.(Berl.), 2010;213:49 PMID: 20217056