WY 14643

Name: WY 14643
Brand: Tocris Bioscience
SKU: 1312

Tocris Bioscience, part of Bio-Techne | Catalog # 1312

Citations (33)

COA / SDS

Selective PPARα agonist

Key Product Details

Chemical Name:	[[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid
Purity:	≥98%
Molecular Weight:	323.8 kDa

View Full Technical Details for WY 14643

Technical Data
Citations

Biological Activity for WY 14643

WY 14643 is a selective PPARα agonist (EC₅₀ values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.

Technical Data for WY 14643

M. Wt	323.8 kDa
Formula	C₁₄H₁₄ClN₃O₂S
Storage	Store at RT
Purity	≥98%
CAS Number	50892-23-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WY 14643

Solubility

Soluble Soluble to 100 mM in DMSO

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References for WY 14643

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Li Y, Wong K, Walsh K, Gao B, Zang M Retinoic acid receptor beta stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. J Biol Chem, 2013;288(15):10490-504. 2013 PMID: 23430257
Willson et al. The PPARs: from orphan receptors to drug discovery. J.Med.Chem., 2000;43:527 PMID: 10691680
Bishop-Bailey Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol., 2000;129:823 PMID: 10696077
Forman et al. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc.Natl.Acad.Sci.U.S.A., 1997;94:4312 PMID: 9113986