XIE62-1004

Name: XIE62-1004
Brand: Tocris Bioscience
SKU: 7878

Tocris Bioscience, part of Bio-Techne | Catalog # 7878

Citations (1)

COA / SDS

Inducer of autophagy via interaction of p62 and LC3

Key Product Details

Description:	Inducer of autophagy via interaction of p62 and LC3
Chemical Name:	2-[[[3,4-Bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	399.91

View Full Technical Details for XIE62-1004

Technical Data
Citations

Biological Activity for XIE62-1004

XIE62-1004 is an inducer of p62-LC3 interaction. Binds to the ZZ domain of p62, leading to p62 self-aggregation and interaction with LC3 on autophagosome membranes; facilitates delivery of cargo proteins to the autophagosome for degradation. Active in vitro and in vivo in a concentration- and time-dependent manner and is specific for wild type p62. Induces degradation of mutant huntingtin in vitro. Can also be used in AUTAC protein degradation systems to induce autophagy through p62 self-aggregation and LC3 interaction.

Technical Data for XIE62-1004

M. Wt	399.91
Formula	C₂₃H₂₅NO₃.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2421146-32-7
PubChem ID	126601715
InChi Key	ROURICFSUKPJOO-UHFFFAOYSA-N
Smiles	Cl.OCCNCC1=CC=C(OCC=2C=CC=CC2)C(OCC=3C=CC=CC3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for XIE62-1004

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8	20

Preparing Stock Solutions for XIE62-1004

The following data is based on the product molecular weight 399.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.50 mL	62.51 mL	125.03 mL
1 mM	2.50 mL	12.50 mL	25.01 mL
2 mM	1.25 mL	6.25 mL	12.50 mL
10 mM	0.25 mL	1.25 mL	2.50 mL

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References for XIE62-1004

References are publications that support the biological activity of the product.

Cha-Molstad p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis. Nat.Commun. 2017 PMID: 28740232
Zhang ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat.Commun. 2018 PMID: 30349045