Z-Guggulsterone

Name: Z -Guggulsterone
Brand: Tocris Bioscience
SKU: 3570

Tocris Bioscience, part of Bio-Techne | Catalog # 3570

Citations (2)

COA / SDS

Broad spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat. No. 2013)

Key Product Details

Chemical Name:	(Z)-Pregna-4,17(20)-diene-3,16-dione
Purity:	≥98%
Molecular Weight:	312.45 kDa

View Full Technical Details for Z-Guggulsterone

Technical Data
Citations

Biological Activity for Z-Guggulsterone

Z-Guggulsterone is a broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (K_i values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (K_i = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. More active isomer of guggulsterone (Cat. No. 2013).

Technical Data for Z-Guggulsterone

M. Wt	312.45 kDa
Formula	C₂₁H₂₈O₂
Storage	Store at RT
Purity	≥98%
CAS Number	39025-23-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Z-Guggulsterone

Solubility

Soluble Soluble to 20 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming

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References for Z-Guggulsterone

References are publications that support the biological activity of the product.

Singh et al. Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate-dependent activation of c-Jun NH₂-terminal kinase. Cancer Res., 2007;67:7439 PMID: 17671214
Xiao and Singh z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol.Cancer Ther., 2008;7:171 PMID: 18202020