ZD 7155 hydrochloride

Name: ZD 7155 hydrochloride
Brand: Tocris Bioscience
SKU: 1211

Tocris Bioscience, part of Bio-Techne | Catalog # 1211

Citations (6)

COA / SDS

Selective non-peptide AT1 antagonist

Key Product Details

Description:	Selective non-peptide AT₁ antagonist
Chemical Name:	5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	474.99

View Full Technical Details for ZD 7155 hydrochloride

Technical Data
Citations

Biological Activity for ZD 7155 hydrochloride

ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT₁) receptor. Displaces [¹²⁵I]-angiotensin II binding with an IC₅₀ value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT₁ antagonist, losartan.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data for ZD 7155 hydrochloride

M. Wt	474.99
Formula	C₂₆H₂₆N₆O.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	146709-78-6
PubChem ID	9826191
InChi Key	NAGGAAHTUXEGFG-UHFFFAOYSA-N
Smiles	Cl.CCC1=CC2=C(CCC(=O)N2CC2=CC=C(C=C2)C2=CC=CC=C2C2=NN=NN2)C(CC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZD 7155 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	4.75	10 with gentle warming

Preparing Stock Solutions for ZD 7155 hydrochloride

The following data is based on the product molecular weight 474.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.05 mL	105.27 mL	210.53 mL
0.5 mM	4.21 mL	21.05 mL	42.11 mL
1 mM	2.11 mL	10.53 mL	21.05 mL
5 mM	0.42 mL	2.11 mL	4.21 mL

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References for ZD 7155 hydrochloride

References are publications that support the biological activity of the product.

Veelken Endogenous angiotensin II and the reflex response to stimulation of cardiopulmonary serotonin 5HT₃ receptors. Br.J.Pharmacol. 1998 PMID: 9886768
Oldham Zeneca ZD7155: a novel, potent and orally-effective angiotensin II receptor antagonist. Br.J.Pharmacol.
Junggren Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and los. in the rat. J.Pharm.Pharmacol. 1996 PMID: 8887734