SenTraGor™

Name: SenTraGor™
Brand: Tocris Bioscience
SKU: 7555

Tocris Bioscience, part of Bio-Techne | Catalog # 7555

COA / SDS

Reagent for staining and detection of lipofuscin in senescent cells

Key Product Details

Description:	Reagent for staining and detection of lipofuscin in senescent cells
Chemical Name:	(2-Methyl-6-((E)-(4-((E)-phenyldiazenyl)naphthalen-1-yl)diazenyl)-2,3-dihydro-1H-perimidin-2-yl)methyl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate
Purity:	≥95% (HPLC)
Molecular Weight:	698.85

View Full Technical Details for SenTraGor™

Technical Data
Citations

Biological Activity for SenTraGor™

SenTraGor^™ is a reagent for detecting lipofuscin in senescent cells. A highly lipophilic and biotinylated analog of Sudan Black B; can be detected using an anti-biotin antibody. Can be used in vivo and in vitro in any biological material including cell cultures, fresh and frozen tissues, and fixed embedded samples. Compatible with immunohistochemistry, flow cytometry and immunofluorescence analysis.

Licensing Information

Sold under license from University of Manchester Innovation Factory

Technical Data for SenTraGor™

M. Wt	698.85
Formula	C₃₉H₃₈N₈O₃S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2171036-89-6
PubChem ID	166603878
InChi Key	NCGWNTJOKSLKQK-SPNFGPMXSA-N
Smiles	[H][C@]12CS[C@H]([C@]1(NC(N2)=O)[H])CCCCC(OCC3(C)NC4=CC=CC5=C4C(N3)=CC=C5/N=N/C6=CC=C(C7=C6C=CC=C7)/N=N/C8=CC=CC=C8)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SenTraGor™

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	6.99	10 with gentle warming
	DMSO	13.98	20

Preparing Stock Solutions for SenTraGor™

The following data is based on the product molecular weight 698.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	7.15 mL	35.77 mL	71.55 mL
1 mM	1.43 mL	7.15 mL	14.31 mL
2 mM	0.72 mL	3.58 mL	7.15 mL
10 mM	0.14 mL	0.72 mL	1.43 mL

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Reconstitution Calculator

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References for SenTraGor™

References are publications that support the biological activity of the product.

Evangelou Robust, universal biomarker assay to detect senescent cells in biological specimens Aging Cell 2017 PMID: 28165661