CKS1: Proteins and Enzymes

CKS1B (Cyclin-dependent kinases regulatory subunit 1) is a 79 amino acid protein that binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. Depleting CKS1B in breast cancer cells has been shown to slow cell cycle progression and regulation of CKS1B may provide a potential cancer treatment option. Besides breast cancer, CKS1B plays a role in multiple myeloma, adenocarcinoma, mantle cell lymphoma , oral squamous cell carcinoma, squamous cell carcinoma, cholesteatoma, paracoccidioidomycosis, intrahepatic cholangiocarcinoma, hepatoblastoma, hepatocellular carcinoma, non-small cell lung carcinoma, gallbladder carcinoma, basal cell carcinoma, endometrial carcinoma, renal cell carcinoma and thyroid carcinoma.