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Cytohesin-1: Proteins and Enzymes
Cytohesin-1, previously called B2-1 or PSCD1 (pleckstrin homology, Sec7 and coiled-coil domain-containing protein 1), is a member of the cytohesin family of guanine nucleotide exchange factors. The Sec7 domain binds the integrin beta 2 subunit cytoplasmic domain, activating integrins via inside-out signaling. It also independently mediates nucleotide exchange. Cytohesin-1 is primarily found in immune system cells.
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