Skip to main content

NUP98 Products

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq]
Show More

44 results for "NUP98" in Products

44 results for "NUP98" in Products

NUP98 Products

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq]
Show More
Applications: WB, ICC/IF, IP
Reactivity: Human
Applications: IHC, WB, ELISA, ICC/IF
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: WB, ICC/IF
Reactivity: Human
Applications: WB
Reactivity: Human, Mouse, Rat

Recombinant Monoclonal Antibody

Applications: WB, IP
Reactivity: Human
Catalog #: H00004928-T02
Applications: WB
Applications: WB, ELISA, MA, AP, PAGE
Applications: WB, ELISA, MA, AP, PAGE
Applications: WB, ELISA, ICC/IF
Reactivity: Human, Mouse
Applications: WB, IP
Reactivity: Human
Applications: ICC/IF
Reactivity: Human
Applications: WB, ELISA
Reactivity: Human, Monkey
Catalog #: H00004928-T03
Applications: WB
Applications: ELISA
Reactivity: Human
Applications: AC
Applications: WB, IP
Reactivity: Human
Applications: WB, IP
Reactivity: Human
Applications: WB, IP
Reactivity: Human
Applications: WB, IP
Reactivity: Human
Applications: WB, IP
Reactivity: Human
Applications: WB, IP
Reactivity: Human
Applications: WB, IP
Reactivity: Human
Applications: WB, IP
Reactivity: Human
Applications: WB, IP
Reactivity: Human
Applications: WB, IP
Reactivity: Human
Results Per Page
5 10 25 50
/ 2