NFkB1 Products
NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.
79 results for "NFkB1" in Products
79 results for "NFkB1" in Products
NFkB1 Products
NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Simple Western |
![Western Blot: NFkB1/NFkB p105 AntibodyBSA Free [NBP1-77395]](https://resources.bio-techne.com/images/products/NFkB1-NFkB-p105-Antibody-Western-Blot-NBP1-77395-img0003.jpg "Western Blot: NFkB1/NFkB p105 AntibodyBSA Free [NBP1-77395]")
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ChIP |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #285412 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: NFkB1/NFkB p105 Antibody [NBP3-05867]](https://resources.bio-techne.com/images/products/NFkB1-NFkB-p105-Antibody-Western-Blot-NBP3-05867-img0001.jpg "Western Blot: NFkB1/NFkB p105 Antibody [NBP3-05867]")
| Reactivity: | Human |
| Details: | Rabbit Polyclonal |
| Applications: | WB |
![Western Blot: NFkB1/NFkB p105 Antibody [NBP3-10287]](https://resources.bio-techne.com/images/products/NFkB1-NFkB-p105-Antibody-Western-Blot-NBP3-10287-img0001.jpg "Western Blot: NFkB1/NFkB p105 Antibody [NBP3-10287]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Simple Western |
| Applications: | ELISA |
| Applications: | ELISA |
Proteasome and calpain inhibitor. Inhibits NF-κB activation
| Chemical Name: | N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide |
| Purity: | ≥95% |
Contains 4 membranes - each spotted in duplicate with 26 different cell stress antibodies
Contains 4 membranes-each spotted in duplicate with 41 different proteins and 4 serine or tyrosine phosphorylation sites antibodies
Inhibits TNF-induced NF-κB activation
| Chemical Name: | 4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol |
| Purity: | ≥98% (HPLC) |
KDM4A inhibitor; also NF-κB activator
| Alternate Names: | D-α-hydroxyglutaric acid disodium salt |
| Chemical Name: | (R)-2-Hydroxypentanedioic acid disodium salt |
Specific inhibitor of NF-κB activation
| Alternate Names: | CAPE |
| Chemical Name: | 3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester |
| Purity: | ≥98% (HPLC) |
NF-κB and AP-1 dual inhibitor
| Chemical Name: | N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide |
| Purity: | ≥99% |
Potent 20S proteasome inhibitor
| Chemical Name: | N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide |
| Purity: | ≥98% |
Inhibits NF-κB activation
| Chemical Name: | (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone |
| Purity: | ≥98% |
Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
| Chemical Name: | 5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid |
| Purity: | ≥97% (HPLC) |
Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
| Chemical Name: | (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid |
Blocks NF-κB activation; also anti-inflammatory and antioxidant
| Chemical Name: | 5,3'-Diallyl-2,4'-dihydroxybiphenyl |
| Purity: | ≥98% |
Inhibitor of NF-κB activation; anti-inflammatory
| Chemical Name: | (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one |
| Purity: | ≥98% (HPLC) |
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
| Chemical Name: | (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one |
| Purity: | ≥98% (HPLC) |
Inhibits TNF-α-induced NF-κB activation
| Chemical Name: | (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid |
| Purity: | ≥99% (HPLC) |
