Nicotinic Acetylcholine R alpha 4/CHRNA4 Products
CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. CHRNA4 is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in CHRNA4 cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in CHRNA4 that provide protection against nicotine addiction have been described.
24 results for "Nicotinic Acetylcholine R alpha 4/CHRNA4" in Products
24 results for "Nicotinic Acetylcholine R alpha 4/CHRNA4" in Products
Nicotinic Acetylcholine R alpha 4/CHRNA4 Products
CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. CHRNA4 is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in CHRNA4 cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in CHRNA4 that provide protection against nicotine addiction have been described.
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SR2141 |
| Applications: | WB, IP |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #7B4H1 |
| Applications: | WB, ELISA |
![Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (7B4H1)BSA Free [NBP2-61674]](https://resources.bio-techne.com/images/products/Nicotinic-Acetylcholine-R-alpha-4-CHRNA4-Antibody-7B4H1-Western-Blot-NBP2-61674-img0003.jpg "Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (7B4H1)BSA Free [NBP2-61674]")
| Reactivity: | Human, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ELISA, IP (-) |
![Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody [NBP1-00143]](https://resources.bio-techne.com/images/products/Nicotinic-Acetylcholine-R-alpha-4-CHRNA4-Antibody-Western-Blot-NBP1-00143-img0003.jpg "Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody [NBP1-00143]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #1C2H2 |
| Applications: | WB |
![Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (1C2H2) [NBP3-15260]](https://resources.bio-techne.com/images/products/Nicotinic-Acetylcholine-R-alpha-4-CHRNA4-Antibody-1C2H2-Western-Blot-NBP3-15260-img0001.jpg "Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (1C2H2) [NBP3-15260]")
| Applications: | WB, ELISA, MA, AP |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody [NBP2-19539]](https://resources.bio-techne.com/images/products/Nicotinic-Acetylcholine-Receptor-alpha-4-Antibody-Western-Blot-NBP2-19539-img0001.jpg "Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody [NBP2-19539]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody [NBP1-80057]](https://resources.bio-techne.com/images/products/Nicotinic-Acetylcholine-R-alpha-4-CHRNA4-Antibody-Western-Blot-NBP1-80057-img0002.jpg "Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody [NBP1-80057]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #4E3 |
| Applications: | WB, ELISA |
![Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (4E3) [H00001137-M01]](https://resources.bio-techne.com/images/products/Nicotinic-Acetylcholine-R-alpha-4-CHRNA4-Antibody-4E3-Western-Blot-H00001137-M01-img0001.jpg "Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (4E3) [H00001137-M01]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody [NBP1-79947]](https://resources.bio-techne.com/images/products/Nicotinic-Acetylcholine-R-alpha-4-CHRNA4-Antibody-Western-Blot-NBP1-79947-img0002.jpg "Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody [NBP1-79947]")
| Reactivity: | Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA |
α4β2, muscle type and Torpedo nAChR antagonist
| Alternate Names: | DHβE |
| Chemical Name: | (2S,13bS)-2-Methoxy-2,3,5,6,8,9,10,13-octahydro-1H,12H-benzo[i]pyrano[3,4-g]indolizin-12-one hydrobromide |
| Purity: | ≥98% (HPLC) |
Selective α4β2 nAChR partial agonist; orally active
| Chemical Name: | 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate |
| Purity: | ≥99% (HPLC) |
α4β2 nAChR ligand; may act as an agonist or a desensitizer
| Chemical Name: | 6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1-ol dihydrochloride |
| Purity: | ≥98% (HPLC) |
Selective α4β2 nAChR agonist
| Alternate Names: | Metanicotine,TC-2403 |
| Chemical Name: | (E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate |
| Purity: | ≥99% (HPLC) |
Selective α4β2 nAChR partial agonist
| Chemical Name: | 4-(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate |
| Purity: | ≥98% (HPLC) |
Selective α4β2 nAChR agonist
| Alternate Names: | Tebanicline |
| Chemical Name: | (R)-5-(Azetidin-2-ylmethoxy)-2-chloropyridine hydrochloride |
| Purity: | ≥98% (HPLC) |
High affinity and subtype-selective α6β2 and α4β2 nAChR partial agonist
| Chemical Name: | (1R,5S)-1,2,3,4,5,6-Hexahydro-3-[2-[(1R,5S)-1,5,6,8-tetrahydro-8-oxo-1,5-methano-2H-pyrido[1,2-a][1,5]diazocin-3(4H)-yl]ethyl]-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of α4β2 nAChRs; also muscle-type nAChR inhibitor
| Chemical Name: | 6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanamine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent α4β4, α4β2 and α7 nAChR agonist
| Chemical Name: | (1R,5S)-9-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one |
| Purity: | ≥98% (HPLC) |
Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
| Chemical Name: | 3-(2-Chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole hydrochloride |
| Purity: | ≥98% (HPLC) |
High affinity and selective α4β2 nAChR partial agonist
| Chemical Name: | 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of α4β2 nAChRs
| Chemical Name: | 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile |
| Purity: | ≥99% (HPLC) |
Potent and selective neuronal nAChRagonist
| Chemical Name: | (1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one |
| Purity: | ≥99% (HPLC) |
