Vanilloid R1/TRPV1: Small Molecules and Peptides
Vanilloid Receptor 1 (VR1) also known as TRPV1 (Transient Receptor Potential Vanilloid 1) and capsaicin receptor, is a 115 kDa integral membrane ion channel that has six transmembrane domains and contains intracellular N-and C-termini. Vanilloid Receptor 1 contributes to normal pain and temperature sensation and also has a sensory-effector function. By alternative splicing, at least three VR1 isoforms are known. The sequence of residues 4 - 21 of rat VR1 is 78% and 28% identical to that of mouse and human VR1, respectively.
16 results for "Vanilloid R1/TRPV1 Small Molecules and Peptides" in Products
16 results for "Vanilloid R1/TRPV1 Small Molecules and Peptides" in Products
Vanilloid R1/TRPV1: Small Molecules and Peptides
Vanilloid Receptor 1 (VR1) also known as TRPV1 (Transient Receptor Potential Vanilloid 1) and capsaicin receptor, is a 115 kDa integral membrane ion channel that has six transmembrane domains and contains intracellular N-and C-termini. Vanilloid Receptor 1 contributes to normal pain and temperature sensation and also has a sensory-effector function. By alternative splicing, at least three VR1 isoforms are known. The sequence of residues 4 - 21 of rat VR1 is 78% and 28% identical to that of mouse and human VR1, respectively.
| Applications: | WB |
Endogenous and non-selective CB agonist
| Alternate Names: | Arachidonylethanolamide,AEA |
| Chemical Name: | N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide |
| Purity: | ≥98% (HPLC) |
TRPV agonist
| Chemical Name: | (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide |
| Purity: | ≥98% (HPLC) |
Potent and selective TRPV1 competitive antagonist
| Chemical Name: | (2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide |
| Purity: | ≥98% (HPLC) |
Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor
| Chemical Name: | 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt |
| Purity: | ≥95% (HPLC) |
Potent TRPV1 antagonist
| Chemical Name: | N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide |
| Purity: | ≥98% (HPLC) |
TRPV antagonist; also activator of ENaCδ
| Chemical Name: | N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide |
| Purity: | ≥99% (HPLC) |
Potent and selective TRPV1 competitive antagonist
| Chemical Name: | 4'-Chloro-3-methoxycinnamanilide |
| Purity: | ≥99% (HPLC) |
TRPV1 antagonist
| Chemical Name: | 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective TRPV1 antagonist
| Chemical Name: | 3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide |
| Purity: | ≥99% (HPLC) |
Reversible, competitive and potent TRPV1 antagonist
| Chemical Name: | 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide |
| Purity: | ≥99% (HPLC) |
Potent and selective TRPV1 antagonist
| Chemical Name: | 3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone |
| Purity: | ≥97% (HPLC) |
Potent TRPV1 antagonist; also antioxidant; activates Nrf2/ARE signaling
| Chemical Name: | 2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
Potent TRPV1 antagonist
| Chemical Name: | N-5-Isoquinolinyl-N'-[[(4-(trifluoromethyl)phenyl]methyl]urea |
| Purity: | ≥98% (HPLC) |
Potent and selective endogenous TRPV1 agonist
| Alternate Names: | N-Oleoyldopamine |
| Chemical Name: | (9Z)-N-[2-(3,4-Dihydroxyphenyl)ethyl]-9-octadecenamide |
| Purity: | ≥98% (HPLC) |
Potent TRPV agonist
| Alternate Names: | NE 19550 |
| Chemical Name: | N-Vanillyloleoylamide |
| Purity: | ≥98% (HPLC) |
