ABCB5 Antibody (CL13618) [Unconjugated]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-43642

Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL13618

Concentration

1 mg/ml

View all ABCB5 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a Synthetic Peptide of Q2M3G0. Actual immunogen sequence is proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for ABCB5 Antibody (CL13618) [Unconjugated]

ABCB5 Antibody (CL13618) [Unconjugated] Immunohistochemistry-Paraffin: ABCB5 Antibody (CL13618) [NBP3-43642]

Immunohistochemistry-Paraffin: ABCB5 Antibody (CL13618) [NBP3-43642]

Staining of human breast shows strong membranous positivity in glandular cells.
ABCB5 Antibody (CL13618) [Unconjugated] Immunohistochemistry-Paraffin: ABCB5 Antibody (CL13618) [NBP3-43642]

Immunohistochemistry-Paraffin: ABCB5 Antibody (CL13618) [NBP3-43642]

Staining of human epididymis shows strong membranous positivity in glandular cells.
ABCB5 Antibody (CL13618) [Unconjugated] Immunohistochemistry-Paraffin: ABCB5 Antibody (CL13618) [NBP3-43642]

Immunohistochemistry-Paraffin: ABCB5 Antibody (CL13618) [NBP3-43642]

Staining of human eye retina shows strong positivity in the nerve fiber layer.
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Applications for ABCB5 Antibody (CL13618) [Unconjugated]

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ABCB5

ATP-Binding Cassette proteins comprise a superfamily of transporters with a wide variety of substrates. ABCB5 is a novel member of the human P-glycoprotein family. It functions as a determinant of membrane potential and regulator of cell fusion in physiologic skin progenitor cells. Cell fusion is thought to contribute to tissue differentiation. ABCB5 is predominantly expressed in melanoma cells and is a novel molecular marker for a distinct subset of chemoresistant stem cell phenotype-expressing tumor cells among human epidermal melanocytes. It has been identified as a novel drug transporter in human malignant melanoma. ABCB5 is a rhodamine efflux transporter. This antibody product is intended to be used to confirm cellular localization and expression level of ABCB5.

Long Name

ATP-binding Cassette, Sub-family B (MDR/TAP), Member 5

Alternate Names

ABCB5 P-gp, ABCB5alpha, ABCB5beta, ATP-binding cassette protein, ATP-binding cassette sub-family B member 5, ATP-binding cassette, sub-family B (MDR/TAP), member 5, EC 3.6.3, EC 3.6.3.44, EST422562, P-glycoprotein ABCB5

Gene Symbol

ABCB5

Additional ABCB5 Products

Product Documents for ABCB5 Antibody (CL13618) [Unconjugated]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ABCB5 Antibody (CL13618) [Unconjugated]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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