ABCC5 Antibody (M5I-1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-42346

Novus Biologicals, part of Bio-Techne
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NBP1-42346
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2A Clone # M5I-1

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all ABCC5 Antibodies »

Product Specifications

Immunogen

ABCC5 (aa 82-168)

Specificity

Reacts with an internal epitope of ABCC5. Does not cross-react with the human MDR1, MRP1, MRP2 or MRP3 gene products

Clonality

Monoclonal

Host

Rat

Isotype

IgG2A

Applications for ABCC5 Antibody (M5I-1)

Application
Recommended Usage

Flow Cytometry

1:10-1:1000

Immunocytochemistry/ Immunofluorescence

1:20-1:50

Immunohistochemistry

1:20

Immunohistochemistry-Frozen

1:20

Western Blot

1:50
Application Notes
M5I-1 has potential value for detection of MRP5-mediated drug-resistance in human tumor samples. Immunocytochemistry: use 1:20-50 dil. on acetone fixed cytospin preparations. For immunohistochemistry: M5I-1 (use 1:20) on acetone fixed frozen sections can

Formulation, Preparation, and Storage

Purification

Tissue culture supernatant

Formulation

Tissue culture supernatant, 0.7% BSA

Preservative

0.1% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: ABCC5

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq]

Long Name

ATP-binding cassette sub-family C member 5

Alternate Names

EC 7.6.2.-, EC 7.6.2.2, MOAT-C, MRP5, pABC11, SMRP

Gene Symbol

ABCC5

Additional ABCC5 Products

Product Documents for ABCC5 Antibody (M5I-1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for ABCC5 Antibody (M5I-1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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