ADAMTS9 Antibody (D2)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-41677

Novus Biologicals, part of Bio-Techne
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NBP3-41677
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # D2

Concentration

1 mg/ml

View all ADAMTS9 Antibodies »

Product Specifications

Immunogen

Immunized with recombinant Human ADAMTS9 (Uniprot#: Q9P2N4; Cys1727-Leu1935 (Uniprot#: Q9P2N4)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Scientific Data Images for ADAMTS9 Antibody (D2)

ADAMTS9 Antibody (D2)

Western Blot: ADAMTS9 Antibody (D2) [NBP3-41677] -

Western Blot: ADAMTS9 Antibody (D2) [NBP3-41677] - Sample: Recombinant ADAMTS9, Human.
ADAMTS9 Antibody (D2)

Immunohistochemistry-Paraffin: ADAMTS9 Antibody (D2) [NBP3-41677] -

Immunohistochemistry-Paraffin: ADAMTS9 Antibody (D2) [NBP3-41677] - DAB staining on IHC-P; Sample: Human Kidney Tissue; Primary Ab: 20ug/ml NBP3-41677; Second Ab: 2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody

Applications for ADAMTS9 Antibody (D2)

Application
Recommended Usage

Immunohistochemistry

5-20ug/mL

Western Blot

0.5-2ug/mL

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

0.01M PBS, pH7.4, 50% glycerol

Preservative

0.05% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ADAMTS9

ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. ADAMTS9 is closest in homology to ADAMTS20, sharing 54% overall identity, and like ADAMTS20 ADAMTS9 gas a GON like domain at the carboxyterminal end. The GON domain at the carboxyterminal end is similar to the GON1 protein in C. elegans, mutations of which lead to defective gonadal development. ADAMTS9 is expressed in ovary and testis, but little is known about the role of ADAMTS9 in reproductive organs. ADAMTS9 is also expressed in the heart, placenta, lung, skeletal tissue, and pancreas, so the protein must have wider functions than just gonadal development. ADAMTS9, like ADAMTS20, has a total of 15 thrombospondin like domains. The first TS domain begins shortly after the catalytic and disintegrin domains. TS domains 2 to 6 follow a spacer domain, followed by linker domain 1, then TS domains 7 & 8, linker domain 2, and then TS domains 9 to 15. In other ADAMTS proteins the TS motifs are thought to bind to the ECM. The ADAMTS proteins contain at least one prohormone convertase cleavage site, although it appears that one site is used preferentially, and cleavage of the propeptide domain at this site generates active enzymes. For ADAMTS9, this site is the RRTKR sequence, and the mature ADAMTS9 has an aminoterminal sequence of FLSYPR. The catalytic site of ADAMTS9 is most like ADAMTS1, 14 and 15, with an HExxHVFNMxH sequence, perhaps giving these enzymes some shared specificity.

Alternate Names

ADAM metallopeptidase with thrombospondin type 1 motif, 9, ADAMTS-9,9, FLJ42955

Gene Symbol

ADAMTS9

Additional ADAMTS9 Products

Product Documents for ADAMTS9 Antibody (D2)

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Certificate of Analysis

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Product Specific Notices for ADAMTS9 Antibody (D2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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