AGAP2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-85686

Novus Biologicals, part of Bio-Techne
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NBP1-85686
NBP1-85686-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (95%), Rat (95%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all AGAP2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: PSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for AGAP2 Antibody

Immunocytochemistry/ Immunofluorescence: AGAP2 Antibody [NBP1-85686]

Immunocytochemistry/ Immunofluorescence: AGAP2 Antibody [NBP1-85686]

Immunocytochemistry/Immunofluorescence: AGAP2 Antibody [NBP1-85686] - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleus, nucleoli & mitochondria. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: AGAP2 Antibody [NBP1-85686]

Immunohistochemistry-Paraffin: AGAP2 Antibody [NBP1-85686]

Immunohistochemistry-Paraffin: AGAP2 Antibody [NBP1-85686] - Staining of human skeletal muscle shows very weak cytoplasmic positivity in myocytes.
Immunohistochemistry-Paraffin: AGAP2 Antibody [NBP1-85686]

Immunohistochemistry-Paraffin: AGAP2 Antibody [NBP1-85686]

Immunohistochemistry-Paraffin: AGAP2 Antibody [NBP1-85686] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.
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Applications for AGAP2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: AGAP2

AGAP2 (also known as centaurin-gamma1, ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2, Phosphatidyl-inositol-3-kinase enhancer, PIKE, GTP-binding and GTPase activating protein 2 and GGAP2) is a GTPase activating protein that inactivates Arf. The expression of AGAP2 is amplified in human glioblastoma cells. AGAP2 protein binds to and activates the protein kinase Akt and prevents apoptosis of cancer cells. AGAP2 also increases motility and invasive activity of cancer cells. AGAP2 may serve as a diagnostic and therapeutic target of human cancer.

Alternate Names

AGAP-2, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2, arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, centaurin, gamma 1, Centaurin-gamma-1, CENTG1, cnt-g1, FLJ16430, GGAP2, GTP-binding and GTPase activating protein 2, GTP-binding and GTPase-activating protein 2, KIAA0167, Phosphatidylinositol-3-kinase enhancer, phosphoinositide 3-kinase enhancer, PIKEArf GAP with GTP-binding protein-like, ANK repeat and PH domains 2

Entrez Gene IDs

116986 (Human)

Gene Symbol

AGAP2

UniProt

Q99490 (Human)

Additional AGAP2 Products

Product Documents for AGAP2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for AGAP2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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