AIMP2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27094

Novus Biologicals, part of Bio-Techne
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NBP2-27094
NBP2-27094SS
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Key Product Details

Species Reactivity

Validated:

Human, Primate

Predicted:

Chimpanzee (100%), Monkey (94%), Orangutan (100%), Rhesus Macaque (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all AIMP2 Antibodies »

Product Specifications

Immunogen

A portion of amino acids 140-190 from human AIMP2 was used as the immunogen for this antibody.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for AIMP2 Antibody

Western Blot: AIMP2 Antibody [NBP2-27094]

Western Blot: AIMP2 Antibody [NBP2-27094]

Western Blot: AIMP2 Antibody [NBP2-27094] - Analysis of AIMP2 using AIMP2 antibody. Human spleen tissue lysate in the 1) absence and 2) presence of immunizing peptide probed with 2 ug/ml of AIMP2 antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Applications for AIMP2 Antibody

Application
Recommended Usage

Western Blot

2-4ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: AIMP2

AIMP2, short for aminoacyl tRNAse synthetase complex-interacting multifunctional protein 2, is also called JTV1 and first identified as the p38 component of the macromolecular complex of tRNA synthetases (1). Along with AIMP1 and AIMP3, AIMP2 forms a trio of auxiliary proteins bound to the aminoacyl tRNase synthetase complex. AIMP1 has already been identified as a pleiotropic cytokine that enhances TLR1, TLR2, TLR3 and TLR7 expression in BM-DCs. AIMP1 also enhances DC production of IL-6 and IL-12 and increases NF-kB activity (2). AIMP2 appears to enhance TNFa induced apoptosis via degradation of TRAF2 (3). It also counters proliferative effects of TGFb imparted by down regulation of c-Myc (3). Reduction of AIMP2 levels in AIMP2 heterozygous or homozygous mice led to higher susceptibility to tumor growth. AIMP2 levels being inversely proportion to the apoptotic process, proliferation and tumorigenesis, implicate AIMP2 as a tumor suppressor. Taken together with the finding that AIMP1 and AIMP3 mutations or allelic deletions are reported in cancer patients (4) (and perhaps similarly AIMP2 as well) bolster the concept of AIMP2 as a potential target for its enhanced expression in development of anti-cancer reagents.

Alternate Names

aminoacyl tRNA synthase complex-interacting multifunctional protein 2, aminoacyl tRNA synthetase complex-interacting multifunctional protein 2, ARS-interacting multi-functional protein 2, JTV1JTV-1, Multisynthase complex auxiliary component p38, multisynthetase complex auxiliary component p38, P38, PRO0992, Protein JTV-1

Gene Symbol

AIMP2

UniProt

Q13155 (Human)

Additional AIMP2 Products

Product Documents for AIMP2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for AIMP2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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