Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (100%). Backed by our 100% Guarantee.

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all Akirin2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide near the center of the human Akirin2. The immunogen is located within amino acids 80 - 130 of Akirin2. Amino Acid Squence: ETSFQQTDPCCTSDA

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Akirin2 Antibody - BSA Free

Western Blot: Akirin2 AntibodyBSA Free [NBP1-76347]

Western Blot: Akirin2 AntibodyBSA Free [NBP1-76347]

Western Blot: Akirin2 Antibody [NBP1-76347] - Human Brain tissue lysate with Akirin2 antibody at 0.5 ug/ml in (A) the absence and (B) the presence ofblocking peptide.

Applications for Akirin2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

0.5 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Akirin2

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Alternate Names

akirin 2, akirin-2, C6orf166, chromosome 6 open reading frame 166, dJ486L4.2, FBI1, FLJ10342, fourteen-three-three beta interactant 1

Gene Symbol

AKIRIN2

UniProt

EAW48578 (Human)

Additional Akirin2 Products

Product Documents for Akirin2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Akirin2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.