alpha 2-Macroglobulin Antibody (A2M/3621) [Janelia Fluor® 549]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08688JF549

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry-Paraffin, Protein Array

Label

Janelia Fluor 549

Antibody Source

Monoclonal Mouse IgG2c Kappa Clone # A2M/3621

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all alpha 2-Macroglobulin Antibodies »

Product Summary for alpha 2-Macroglobulin Antibody (A2M/3621) [Janelia Fluor® 549]

Immunogen

Human recombinant alpha 2-Macroglobulin protein fragment (around aa604-748) (exact sequence is proprietary) (Uniprot: P01023)

Localization

Secreted in plasma

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2c Kappa

Applications for alpha 2-Macroglobulin Antibody (A2M/3621) [Janelia Fluor® 549]

Application
Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Protein Array

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: alpha 2-Macroglobulin

Alpha 2 macroglobulin is a serum protein which is mainly synthesised in the liver. It functions as a broad range irreversible proteinase inhibitor that forms a "trap" around most proteases. Alpha 2 macroglobulin is is a tetrameric molecule, and with a molecular weight of 720 kDa, it so large a molecule that it tends to remain intravascular. Following conformational change, the protinase is deposited within a central cavity where it is still active but prevented from further contact with its substrate. Removal of the complex is mediated by the generation of recognition sites which react with receptors on a variety of cells including macrophages and liver cells. Alpha 2 macroglobulin is localized on the surface of peripheral blood lymphocytes.

Alternate Names

A2M, alpha 2Macroglobulin, CPAMD5

Gene Symbol

A2M

Additional alpha 2-Macroglobulin Products

Product Documents for alpha 2-Macroglobulin Antibody (A2M/3621) [Janelia Fluor® 549]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for alpha 2-Macroglobulin Antibody (A2M/3621) [Janelia Fluor® 549]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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