Androgen R/NR3C4 Antibody (SPM335) [Janelia Fluor® 525]
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-47855JF525
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Human, Mouse (Negative)
Applications
CyTOF-ready, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin
Label
Janelia Fluor 525
Antibody Source
Monoclonal Mouse IgG1 kappa Clone # SPM335
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
A synthetic peptide, aa 302-318 (STEDTAEYSPFKGGYTK) of human Androgen R/NR3C4 (Uniprot: P10275)
Reactivity Notes
Does not react with Mouse.
Localization
Nuclear
Specificity
Recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin. This monoclonal antibody is superb for staining of formalin/paraffin tissues.
Marker
Marker of Androgen Dependence
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1 kappa
Applications for Androgen R/NR3C4 Antibody (SPM335) [Janelia Fluor® 525]
Application
Recommended Usage
CyTOF-ready
Optimal dilutions of this antibody should be experimentally determined.
Flow Cytometry
Optimal dilutions of this antibody should be experimentally determined.
Immunocytochemistry/ Immunofluorescence
Optimal dilutions of this antibody should be experimentally determined.
Immunofluorescence
Optimal dilutions of this antibody should be experimentally determined.
Immunohistochemistry
Optimal dilutions of this antibody should be experimentally determined.
Immunohistochemistry-Paraffin
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: Androgen R/NR3C4
Long Name
Androgen Receptor
Alternate Names
AIS, AndrogenR, AR, DHTR, NR3C4, SBMA, SMAX1
Gene Symbol
AR
Additional Androgen R/NR3C4 Products
Product Documents for Androgen R/NR3C4 Antibody (SPM335) [Janelia Fluor® 525]
Product Specific Notices for Androgen R/NR3C4 Antibody (SPM335) [Janelia Fluor® 525]
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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