Androgen R/NR3C4 Antibody (SPM335) [DyLight 755]

DyLight 755 (Excitation = 754 nm, Emission = 776 nm)

Monoclonal Mouse IgG₁ kappa Clone # SPM335

Please see the vial label for concentration. If unlisted please contact technical services.

A synthetic peptide, aa 302-318 (STEDTAEYSPFKGGYTK) of human Androgen R/NR3C4 (Uniprot: P10275)

Does not react with Mouse.

Nuclear

Recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin. This monoclonal antibody is superb for staining of formalin/paraffin tissues.

Marker of Androgen Dependence

Monoclonal

Mouse

IgG₁ kappa

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Protein A or G purified

50mM Sodium Borate

0.05% Sodium Azide

Please see the vial label for concentration. If unlisted please contact technical services.

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C in the dark.