Apolipoprotein E R2/ApoE R2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-76911

Novus Biologicals, part of Bio-Techne
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NBP2-76911
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all Apolipoprotein E R2/ApoE R2 Antibodies »

Product Summary for Apolipoprotein E R2/ApoE R2 Antibody

Immunogen

Recombinant protein within Human Apolipoprotein E R2/ApoE R2 aa 494-722 / 963. (SwissProt: Q14114 Human; SwissProt: Q924X6 Mouse)

Localization

Cell membrane. Secreted.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

77 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Apolipoprotein E R2/ApoE R2 Antibody

Western Blot: Apolipoprotein E R2/ApoE R2 Antibody [NBP2-76911]

Western Blot: Apolipoprotein E R2/ApoE R2 Antibody [NBP2-76911]

Western Blot: Apolipoprotein E R2/ApoE R2 Antibody [NBP2-76911] - Western blot analysis of ApoER2 on different lysates using anti-ApoER2 antibody at 1/1,000 dilution.Positive control:Lane1: Mouse placentaLane2: SH-SY-5Y
Immunocytochemistry/ Immunofluorescence: Apolipoprotein E R2/ApoE R2 Antibody [NBP2-76911]

Immunocytochemistry/ Immunofluorescence: Apolipoprotein E R2/ApoE R2 Antibody [NBP2-76911]

Immunocytochemistry/Immunofluorescence: Apolipoprotein E R2/ApoE R2 Antibody [NBP2-76911] - ICC staining ApoER2 in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Immunohistochemistry: Apolipoprotein E R2/ApoE R2 Antibody [NBP2-76911]

Immunohistochemistry: Apolipoprotein E R2/ApoE R2 Antibody [NBP2-76911]

Immunohistochemistry: Apolipoprotein E R2/ApoE R2 Antibody [NBP2-76911] - Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-ApoER2 antibody. Counter stained with hematoxylin.
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Applications for Apolipoprotein E R2/ApoE R2 Antibody

Application
Recommended Usage

Flow Cytometry

1:50-1:100

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry-Paraffin

1:50

Western Blot

1:500-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH7.4), 0.2% BSA, 50% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Apolipoprotein E R2/ApoE R2

Apolipoprotein E Receptor 2 (ApoER2), also known as LRP8, is a Low-density lipoprotein receptor family member involved in endocytosis and signal transduction. Specifically, ApoER-2 is responsible for the cellular recognition and internalization of ApoE containing lipoproteins, including VLDL and HDL.

ApoER2 is expressed mainly in the brain, placenta, platelets and megakaryocytic cells, but not in the liver. LRP8 mutations can cause myocardial infarction type 1 (MCI1), a condition characterized by the irreversible necrosis of heart muscle secondary to prolonged ischemia. ApoER2 may also play a role in debilitating neurodegenerative diseases such as schizophrenia and Alzheimer's disease.

ApoER2 antibodies are useful tools for studying certian cardiac and neurodegenerative diseases.

Long Name

Apolipoprotein E Receptor 2

Alternate Names

ApoER2, Lr8b, LRP-8, LRP8

Gene Symbol

LRP8

Additional Apolipoprotein E R2/ApoE R2 Products

Product Documents for Apolipoprotein E R2/ApoE R2 Antibody

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Certificate of Analysis

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Product Specific Notices for Apolipoprotein E R2/ApoE R2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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