ARMER Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00023204-B02P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ARMER Antibodies »

Product Specifications

Immunogen

ARL6IP1 (NP_055976.1, 1 a.a. - 203 a.a.) full-length human protein. MAEGDNRSTNLLAAETASLEEQLQGWGEVMLMADKVLRWERAWFPPAIMGVVSLVFLIIYYLDPSVLSGVSCFVMFLCLADYLVPILAPRIFGSNKWTTEQQQRFHEICSNLVKTRRRAVGWWKRLFTLKEEKPKMYFMTMIVSLAAVAWVGQQVHNLLLTYLIVTSLLLLPGLNQHGIILKYIGMAKREINKLLKQKEKKNE

Specificity

ARL6IP1 - ADP-ribosylation factor-like 6 interacting protein 1,

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for ARMER Antibody

Western Blot: ARMER Antibody [H00023204-B02P]

Western Blot: ARMER Antibody [H00023204-B02P]

Western Blot: ARMER Antibody [H00023204-B02P] - Analysis of ARL6IP expression in human liver.
Western Blot: ARMER Antibody [H00023204-B02P]

Western Blot: ARMER Antibody [H00023204-B02P]

Western Blot: ARMER Antibody [H00023204-B02P] - Analysis of ARL6IP1 expression in transfected 293T cell line by ARL6IP1 polyclonal antibody. Lane 1: ARL6IP transfected lysate(22.33 KDa). Lane 2: Non-transfected lysate.

Applications for ARMER Antibody

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: ARMER

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Alternate Names

ADP-ribosylation factor-like 6 interacting protein, ADP-ribosylation factor-like 6 interacting protein 1, AIP1, Aip-1, apoptotic regulator in the membrane of the endoplasmic reticulum, ARL-6-interacting protein 1, ARL6IPaip-1, ARMER, KIAA0069ADP-ribosylation factor-like protein 6-interacting protein 1

Entrez Gene IDs

23204 (Human)

Gene Symbol

ARL6IP1

UniProt

NP_055976.1 (Human)

Additional ARMER Products

Product Documents for ARMER Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for ARMER Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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