Asialoglycoprotein Receptor 2 Antibody (002)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-06211

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 002

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ASGR2 Antibodies »

Product Specifications

Immunogen

This antibody was obtained from a rabbit immunized with purified, recombinant Human Asialoglycoprotein Receptor 2 (Uniprot#: P07307-1; Gln80-Ala311).

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This antibody can be stored at 2C-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Avoid repeated freeze-thaw cycles.

Scientific Data Images for Asialoglycoprotein Receptor 2 Antibody (002)

Immunocytochemistry/ Immunofluorescence: Asialoglycoprotein Receptor 2 Antibody (002) [NBP3-06211]

Immunocytochemistry/ Immunofluorescence: Asialoglycoprotein Receptor 2 Antibody (002) [NBP3-06211]

Immunocytochemistry/Immunofluorescence: Asialoglycoprotein Receptor 2 Antibody (002) [NBP3-06211] - Immunofluorescence staining of ASGR2 in HepG2 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-human ASGR2 monoclonal antibody (1:60) at 4 degrees celsius overnight. Then cells were stained with the Alexa Fluor (TM) 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).
Immunohistochemistry-Paraffin: Asialoglycoprotein Receptor 2 Antibody (002) [NBP3-06211]

Immunohistochemistry-Paraffin: Asialoglycoprotein Receptor 2 Antibody (002) [NBP3-06211]

Immunohistochemistry-Paraffin: Asialoglycoprotein Receptor 2 Antibody (002) [NBP3-06211] - Staining of human ASGR2 in human liver with rabbit monoclonal antibody (1:200).
Flow Cytometry: Asialoglycoprotein Receptor 2 Antibody (002) [NBP3-06211]

Flow Cytometry: Asialoglycoprotein Receptor 2 Antibody (002) [NBP3-06211]

Flow Cytometry: Asialoglycoprotein Receptor 2 Antibody (002) [NBP3-06211] - Flow cytometric analysis of Human ASGR2 expression on HepG2 cells. Cells were stained with purified anti-Human ASGR2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
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Applications for Asialoglycoprotein Receptor 2 Antibody (002)

Application
Recommended Usage

ELISA

1:5000-1:10000

Flow Cytometry

1:25-1:100

Immunocytochemistry/ Immunofluorescence

1:20-1:100

Immunohistochemistry-Paraffin

1:100-1:500

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 um filtered solution in PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ASGR2

Asialoglycoprotein Receptor 2 is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of plasma glycoproteins in which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. It is expressed exclusively in hepatic parenchymal cells and calcium is required for ligand binding. Asialoglycoprotein Receptor 2 may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. Asialoglycoprotein Receptor 2 is involved in hepatitis B, hepatitis C, liver cirrhosis, hepatocellular carcinoma, nephropathy, leukemia, urethritis, autoimmune hepatitis, alcoholic liver cirrhosis, and jaundice.

Long Name

Asialoglycoprotein Receptor 2

Alternate Names

ASGPR2, CLEC4H2, HBXBP

Gene Symbol

ASGR2

Additional ASGR2 Products

Product Documents for Asialoglycoprotein Receptor 2 Antibody (002)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Asialoglycoprotein Receptor 2 Antibody (002)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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