Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Primate (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunoprecipitation, Western Blot (Negative)

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

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Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 1 and 50 of human Ataxin 10 (spinocerebellar ataxia 10) using the numbering given in entry NP_037368.1 (GeneID 25814).

Reactivity Notes

Orangutan (100%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Ataxin-10 Antibody

Immunoprecipitation: Ataxin-10 Antibody [NB100-57491]

Immunoprecipitation: Ataxin-10 Antibody [NB100-57491]

Immunoprecipitation: Ataxin-10 Antibody [NB100-57491] - Detection of Human Ataxin-10 by Western Blot of Immunoprecipitates. Whole cell lysates from Hela cells loaded (1 mg, 20% of IP). Ataxin-10 antibody (NB100-57491) used for IP at 3 ug/mg lysate. Ataxin-10 was also immunoprecipitated by rabbit Ataxin-10 antibody NB100-57492, which recognizes a downstream epitope. For blotting NB100-57492 was used at 0.1 ug/ml.

Applications for Ataxin-10 Antibody

Application
Recommended Usage

Immunoprecipitation

2-5 ug/mg lysate

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Ataxin-10

Pentanucleotide repeat expansions in the ATXN10/SCA10 gene have been linked to spinocerebellar ataxia type 10, a disorder that is characterized by gait ataxia, cognitive development, and seizures. ATXN10/SCA10 is an evolutionarily conserved protein whose function has not been identified. It is proposed that the repeats in ATXN10/SCA10 may form unusual RNA hairpin structures that result in toxic RNA that may have biological effects such as sequestering of proteins, activation of enzymes, and deregulation of gene expression via the RNA interference pathway. ATXN10/SCA10 is also known as ataxin-10, spinocerebellar ataxia type 10 protein, brain protein E46 homolog, E46L, and FLJ37990.

Alternate Names

ataxin 10, ataxin-10, Brain protein E46 homolog, E46L, FLJ37990, HUMEEP, SCA10spinocerebellar ataxia 10, Spinocerebellar ataxia type 10 protein

Entrez Gene IDs

25814 (Human)

Gene Symbol

ATXN10

UniProt

Q9UBB4 (Human)

Additional Ataxin-10 Products

Product Documents for Ataxin-10 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Ataxin-10 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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