ATG4A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-42518

Novus Biologicals, part of Bio-Techne
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NBP2-42518
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all ATG4A Antibodies »

Product Specifications

Immunogen

Peptide with sequence TEENGTVNDQTFHC corresponding to internal region according to NP_443168.2, NP_840054.1.

Specificity

This antibody is expected to recognize both reported isoforms (NP_443168.2; NP_840054.1)

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for ATG4A Antibody

Immunohistochemistry-Paraffin: ATG4A Antibody [NBP2-42518]

Immunohistochemistry-Paraffin: ATG4A Antibody [NBP2-42518]

Immunohistochemistry-Paraffin: ATG4A Antibody [NBP2-42518] - Analysis of Human Liver shows textured cytoplasm staining in the hepatocytes.

Applications for ATG4A Antibody

Application
Recommended Usage

Immunohistochemistry

2 - 4 ug/ml

Immunohistochemistry-Paraffin

2 - 4 ug/ml

Peptide ELISA

Detection limit 1:1000
Application Notes
IHC-P: Human liver shows textured cytoplasm staining in the hepatocytes.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: ATG4A

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.; FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.; ENZYME REGULATION: Inhibited by N-ethylmaleimide; SUBCELLULAR LOCATION: Cytoplasm;

Long Name

ATG4 Autophagy Related 4 Homolog A

Alternate Names

Apg4a, Atg4al, Autl2, Autophagin 2

Entrez Gene IDs

115201 (Human)

Gene Symbol

ATG4A

Additional ATG4A Products

Product Documents for ATG4A Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ATG4A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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