ATP7b Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48523

Novus Biologicals, part of Bio-Techne
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NBP2-48523
NBP2-48523-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ATP7b Antibodies »

Product Summary for ATP7b Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: RKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ATP7b Antibody

Immunohistochemistry-Paraffin: ATP7b Antibody [NBP2-48523]

Immunohistochemistry-Paraffin: ATP7b Antibody [NBP2-48523]

Immunohistochemistry-Paraffin: ATP7b Antibody [NBP2-48523] - Staining of human Liver shows strong granular cytoplasmic positivity in hepatocytes.
Immunohistochemistry-Paraffin: ATP7b Antibody [NBP2-48523]

Immunohistochemistry-Paraffin: ATP7b Antibody [NBP2-48523]

Immunohistochemistry-Paraffin: ATP7b Antibody [NBP2-48523] - Staining of human Cerebellum shows moderate granular cytoplasmic positivity in Purkinje cells.
Immunohistochemistry-Paraffin: ATP7b Antibody [NBP2-48523]

Immunohistochemistry-Paraffin: ATP7b Antibody [NBP2-48523]

Immunohistochemistry-Paraffin: ATP7b Antibody [NBP2-48523] - Staining of human Kidney shows moderate granular cytoplasmic positivity in cells in tubules.
View 1 more images

Applications for ATP7b Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ATP7b

ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; form A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver.

Alternate Names

ATPase, Cu(2+)- transporting, beta polypeptide, ATPase, Cu++ transporting, beta polypeptide, Copper pump 2, copper-transporting ATPase 2, EC 3.6.3, EC 3.6.3.4, PWD, WC1, WD, Wilson disease-associated protein, WNDATPase, Cu++ transporting, beta polypeptide (Wilson disease)

Gene Symbol

ATP7B

Additional ATP7b Products

Product Documents for ATP7b Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ATP7b Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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