ATRIP [p Ser239] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-29537

Novus Biologicals, part of Bio-Techne
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NBP2-29537
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Mouse

Predicted:

Bovine (100%), Human (100%), Primate (100%), Sheep (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ATRIP Antibodies »

Product Summary for ATRIP [p Ser239] Antibody

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser239 conjugated to KLH. Accession # Q8WXE1

Modification

p Ser239

Specificity

Specific for endogenous levels of the ~86 kDa ATRIP protein phosphorylated at Ser239. The antibody also recognizes a band at ~32 kDa.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

86 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for ATRIP [p Ser239] Antibody

Western Blot: ATRIP [p Ser239] Antibody [NBP2-29537]

Western Blot: ATRIP [p Ser239] Antibody [NBP2-29537]

Western Blot: ATRIP [p Ser239] Antibody [NBP2-29537] - Western blot of mouse testis lysate showing specific immunolabeling of the ~86kd ATRIP protein phosphorylated at Ser239 (control). Phosphospecificity is shown in the second lane. The blot is identical to the control except that the lysate was incubated in lambda-Ptase (800 units/1mg protein for 30 min). The immunolabeling is completely eliminated by treatment with lambda-Ptase.

Applications for ATRIP [p Ser239] Antibody

Application
Recommended Usage

Western Blot

1:500
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: ATRIP

ATRIP, ATR interacting protein, binds to ATR to regulate ATR expression, and is an essential component of the DNA damage checkpoint pathway (Cortez et al, 2001). ATR is recruited to DNA lesions in part through its association with ATRIP, which in turn interacts with the single-stranded DNA binding protein RPA (Ball et al, 2007). DNA replication forks may stall as a result of DNA damage causing phosphorylation of several proteins, including BRCA1 when colocalizing with ATR/ATRIP complex and RPA (Venere et al, 2007). The DNA replication fork stall coincides with BRCA1 directly phosphorylating ATRIP at ser239 (Venere et al, 2007).

Long Name

Ataxia Telangiectasia and Rad 3-related Interacting Protein

Alternate Names

TREX1

Gene Symbol

ATRIP

Additional ATRIP Products

Product Documents for ATRIP [p Ser239] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ATRIP [p Ser239] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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