Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all BACE-2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 16 amino acid peptide near the amino terminus of human BACE2. The immunogen is located within amino acids 30 - 80 of BACE2. Amino Acid Squence: APTPGPGTPAERHADG

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

66 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for BACE-2 Antibody - BSA Free

Western Blot: BACE-2 AntibodyBSA Free [NBP1-77309]

Western Blot: BACE-2 AntibodyBSA Free [NBP1-77309]

Western Blot: BACE-2 Antibody [NBP1-77309] - Human (A) and mouse (B) heart tissue lysates with BACE2 antibody at 1 ug/ml.
Immunohistochemistry-Paraffin: BACE-2 Antibody - BSA Free [NBP1-77309]

Immunohistochemistry-Paraffin: BACE-2 Antibody - BSA Free [NBP1-77309]

Immunohistochemistry-Paraffin: BACE-2 Antibody [NBP1-77309] - Mouse heart with BACE2 antibody at 10 ug/ml.
BACE-2 Antibody - BSA Free

Western Blot: BACE-2 Antibody - BSA Free [NBP1-77309] -

Western Blot: BACE-2 Antibody - BSA Free [NBP1-77309] - Western blot analysis of BACE-2 in (A) human and (B) mouse heart tissue lysates with BACE-2 antibody at 1 u/mL.
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Applications for BACE-2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

10 ug/ml

Immunohistochemistry-Paraffin

10 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BACE-2

Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.

Long Name

beta-site Ayloid Precursor Protein Cleaving Enzyme 2

Alternate Names

BACE2

Gene Symbol

BACE2

UniProt

AAF17078 (Human)

Additional BACE-2 Products

Product Documents for BACE-2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for BACE-2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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