BCCIP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-31319

Novus Biologicals, part of Bio-Techne
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NBP1-31319
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all BCCIP Antibodies »

Product Summary for BCCIP Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human BCCIP. The exact sequence is proprietary.

Localization

Nucleus |

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

36 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for BCCIP Antibody

Western Blot: BCCIP Antibody [NBP1-31319]

Western Blot: BCCIP Antibody [NBP1-31319]

Western Blot: BCCIP Antibody [NBP1-31319] - Sample (30 ug of whole cell lysate) A: A431 B: Hela 10% SDS PAGE; antibody diluted at 1:1000.
Immunocytochemistry/ Immunofluorescence: BCCIP Antibody [NBP1-31319]

Immunocytochemistry/ Immunofluorescence: BCCIP Antibody [NBP1-31319]

Immunocytochemistry/Immunofluorescence: BCCIP Antibody [NBP1-31319] - Paraformaldehyde-fixed HeLa, using antibody at 1:200 dilution.
Immunohistochemistry-Paraffin: BCCIP Antibody [NBP1-31319]

Immunohistochemistry-Paraffin: BCCIP Antibody [NBP1-31319]

Immunohistochemistry-Paraffin: BCCIP Antibody [NBP1-31319] - BCCIP antibody detects BCCIP protein at nucleus on U373 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded U373 xenograft. BCCIP antibody dilution: 1:500. Antigen Retrieval: Trilogy (EDTA based, pH 8.0) buffer, 15min
View 1 more images

Applications for BCCIP Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100-1:1000

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: BCCIP

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Alternate Names

BCCIPalpha, BRCA2 and CDKN1A interacting protein, BRCA2 and CDKN1A-interacting protein, BRCA2 and Cip1/p21 interacting protein, cdk inhibitor p21 binding protein, P21- and CDK-associated protein 1, Protein TOK-1, TOK-1, TOK-1alpha, TOK1BCCIPbeta, TOK-1beta

Gene Symbol

BCCIP

Additional BCCIP Products

Product Documents for BCCIP Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for BCCIP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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