Bcl-10 Antibody (OTI4A8)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-02597

Novus Biologicals, part of Bio-Techne
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NBP2-02597
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI4A8

Concentration

0.73 mg/ml

View all Bcl-10 Antibodies »

Product Summary for Bcl-10 Antibody (OTI4A8)

Immunogen

Full length human recombinant protein of human BCL10 (NP_003912) produced in HEK293T cell.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

26.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Bcl-10 Antibody (OTI4A8)

Western Blot: Bcl-10 Antibody (OTI4A8) [NBP2-02597]

Western Blot: Bcl-10 Antibody (OTI4A8) [NBP2-02597]

Western Blot: Bcl10 Antibody (4A8) [NBP2-02597] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Bcl10 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-Bcl10.
Immunocytochemistry/Immunofluorescence: Bcl10 Antibody (4A8) [NBP2-02597] Staining of COS7 cells transiently transfected by pCMV6-ENTRY Bcl10.
Immunohistochemistry-Paraffin: Bcl-10 Antibody (OTI4A8) [NBP2-02597]

Immunohistochemistry-Paraffin: Bcl-10 Antibody (OTI4A8) [NBP2-02597]

Immunohistochemistry-Paraffin: Bcl10 Antibody (4A8) [NBP2-02597] - Staining of paraffin-embedded Human prostate tissue using anti-Bcl10 mouse monoclonal antibody.
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Applications for Bcl-10 Antibody (OTI4A8)

Application
Recommended Usage

Flow Cytometry

1:100

Immunocytochemistry/ Immunofluorescence

1:100

Immunohistochemistry

1:50

Immunohistochemistry-Paraffin

1:50

Western Blot

1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

0.73 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Bcl-10

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Long Name

B Cell Lymphoma/Leukemia 10

Alternate Names

Bcl10, c-E10, CARMEN, CIPER, CLAP, mE10

Entrez Gene IDs

8915 (Human)

Gene Symbol

BCL10

Additional Bcl-10 Products

Product Documents for Bcl-10 Antibody (OTI4A8)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Bcl-10 Antibody (OTI4A8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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